Firma:              Finnigan

Modell:            TSQ API1 7000

Kommentar:   Dokumente engl.

TSQ® 7000

Triple-Stage Quadrupole Mass Spectrometer

The TSQ 7000 is the next generation in triple-stage quadrupole technology, the most advanced, versatile, and powerful mass spec­trometer available in its class.

The 7000 Series features new, longer quad­rupoles for improved resolution, a non-linear octapole collision cell providing efficient collision-induced dissociation (CID) and neutral noise reduction, an advanced 15 kV conversion dynode detector to enhance sensitivity, and digital signal processing for improved detec­tion limits.

The TSQ also offers the most complete range of sample introduction techniques available for unequaled versatility. Advanced MS/MS capabilities enable you to solve virtually any analytical problem today, and into the future.

Standard Features

Mass Spectrometer

Mass Analyzer

•            High precision 250 mm hyperbolic quadrupole mass analyzers with dual 2500/4000 u mass range, switchable from the data system terminal

•            MS and MS/MS analysis an alternate scans

•            Mass peak position stable to 0.05 u over 8 hours (alter warmup)

Collision Gell

•            Non-linear octapole assembly with 185 mm collision path length for efficient ion fragmentation and neutral noise reduction

•            Ion collision energies of 0 to ±196 eV, program­mable scan-to-scan

•            Innovative cell enclosure provides operating pressures from 0.1 to 10 mTorr (13-1300 mPa)

Detector

•            Post-acceleration conversion dynode with -15 kV or +15 kV applied voltage for detection of positive or negative ions, respectively

•            Off-axis continuous dynode electron multiplier with extended dynamic range, operable to -3000 V

•            Unique direct mounting of the multiplier to the electrometer PCB to eliminate microphonic­induced anode noise

Vacuum System

•            Cradle vacuum system with glass plates sealing the ion source and mass analyzer chambers

•            Hybrid turbomolecular/molecular drag pumps

•            Three inlet ports to simultaneously support GC, Particle Beam, and probe interfaces in EI/CI modes

Acquisition Interface

•            Automatic bandwidth optimization of the analog­to-digital converter (ADC) up to 45 kHz maximum

•            Up to 50,000 digital samples per scan, or 100,000 samples per second, can be acquired at scan rates as high as 4000 u s-'.

•            Programmable digital signal processor (DSP) with 48-bit precision for all data acquisition calculations (including centroiding, averaging, profile data accumulation, background subtraction, and real-time deconvolution) and electronic noise discrimination

•            DSP's 48-bit internal dynamic range yields external dynamic range of 2.6 x 108 for centroid data and 2.38 x 108 for profile data

•            Five analog inputs, two analog outputs, four RS-232 serial interfaces, and three TTL input/output lines for interfacing to other instruments

Data System

Hardware

•            High-performance 64-bit Alpha AXP" RISC-based workstation, with OSF/1® operating system

•            Storage expansion module with high-capacity disk drive, CD-ROM and DAT tape drive

•            High resolution monitor

•            PostScript® laser printer

•            Ethernet" port for connection to mass spectrom­eter and laboratory networks

Software

•            Instrument Control Language'" with GUIDE" step‑by-step control and ICIS"11 applications software—mouse driven or keyboard control, multi-window‑ing environment with Motir graphical user interface

•            TCP/1P networking software for connecting to any remote workstation, including PCs, Macintosh®computers, and X-terminals

Instrument Control

•            All ion path parameters can be programmed with the mass scan. Independent parameter sets can be stored for different Operation modes (e.g., ESI, APCI, El, Cl, positive/negative ion, different collision energies, etc.).

•            Data system control of all major GC, LC, and GC/ LC autosamplers, such as Varian 3400, A200S, HP 5890, Waters 6000/717, HP 1050, TSP 4100, and Michrom. Control includes:

–           setting operating parameters

–           setting up, saving, and downloading methods

–           reading status

– controlling an automated analysis

•            Comprehensive diagnostic programs for real-time analysis of system performance

Performance Specifications

LC/MS Sensitivity

Atmospheric Pressure Chemical Ionization (APCI):

•            A loop injection of 5µL of a 10 pg µL ^-1 solution of reserpine [50 picograms (82 femtomoles) total sample] at 1 mL min ^-1 of 50% methanol/50% water with 1% acetic acid will produce a minimum peak-to-peak signal-to-noise ratio of 10:1 for the protonated molecular ion at m/z 609 when the mass spectrometer is operated in a selected-ion­monitoring mode scanning a 1 dalton wide window at m/z 609 in 0.2 s.

Electrospray (ESI):

•            A loop injection of 1µL of a 50 pg 1.1L ^-1 solution of reserpine [50 picograms (82 femtomoles) total sample] at 200 µL min ^-1 flow of 50% methanol/ 50% water with 1% acetic acid will produce a minimum peak-to-peak signal-to-noise ratio of 10:1 for the protonated molecular ion at m/z 609 when the mass spectrometer is operated in a selected-ion-monitoring mode scanning a 1 dalton wide window at m/z 609 in 0.2 s.

Thermospray (TSP ^TM ):

•            With a mobile phase of 20% methanol/80% water with 0.05 M ammonium acetate buffer at a 1.2-1.5 mL min ^-1 flow rate, the Signal produced by injection of 20 µL of a solution of 0.5 ng µL ^-1 of adenosine into a 20 µL injection loop will yield a minimum peak-to-peak signal-to-noise ratio of 50:1 for the protonated molecular ion at m/z 268 when the mass analyzer is scanned in an MS mode from m/z 120 to 280 in 0.5 s.

Particle Beam Interface (PBI):

•            With an ion source temperature of 250 °C, desolvation chamber temperature of 40 °C, helium gas for nebulization at a pressure of 40 psi, and mobile phase of 100% methanol at a 0.3 mL min ^-1 flow rate, the following specifications will be met:

El: Upon injection of 5 µL of a solution of 2 ng µL ^-1 of caffeine in methanol, the system will produce a minimum peak-to-peak signal-to-noise ratio of 10:1 for the molecular ion at m/z 194 when the mass analyzer is scanned in an MS mode from m/z 65 to 250 in 1 s.

Cl: Upon injection of 5µL of a solution of 2 ng 1.tL-1 of caffeine in methanol, the system will produce a minimum peak-to-peak signal-to-noise ratio of 10:1 for the protonated molecular ion at m/z 195 when the mass analyzer is scanned in an MS mode from m/z 65 to 250 in 1 s.

GC/MS Sensitivity

Electron Ionization (EI):

•            Upon a splitless injection of 200 pg of methyl stearate onto the fused silica capillary column provided with the system, the system will produce a minimum peak-to-peak signal-to-noise ratio of 30:1 for the molecular ion at m/z 298 when Q1 is scanned from m/z 60 to 310 in 0.5 s.

Chemical Ionization (CI):

•            Upon a splitless injection of 100 pg of benzo­phenone onto the fused silica capillary column provided with the system, the system will produce a minimum peak-to-peak signal-to-noise ratio of 25:1 for the protonated molecular ion at m/z 183 when Q1 is scanned from m/z 90 to 240 in 0.5 s using methane as the reagent gas.

MS/MS Efficiency

Collision-Induced Dissociation (CID):

•            Upon a splitless injection of 100 pg benzo­phenone onto the fused silica capillary column provided with the system, the system will produce a minimum peak-to-peak signal-to-noise ratio of 50:1 for the m/z 105 product ion of m/z 183 when the system is operated in the product ion mode and Q3 is scanned from m/z 50 to m/z 185 in 0.5 s using methane as the reagent gas, a colli­sion energy of -20 eV, and a collision gas pres­sure of 1 to 2 mTorr (130-260 mPa).

Optional Features

The versatility and flexibility of the TSQ 7000 are unmatched. A range of options is available, including:

EUCI Ion Source

•            High performance ion source for El, positive ion Cl, and negative ion Cl Operation

•            Patented exchangeable ion volumes allow rapid switchover between EI and Cl

•            Up to 2 mA emission current and electron energies of-l0 to-190V

LC Interfaces

•            Atmospheric Pressure lonization (API) including Electrospray (ESI) and Atmospheric Pressure Chemical lonization (APCI) inlets, providing source fragmentation in either the capillary/skimmer region or source octapole, under complete data system control

•            Particle Beam Interface

•            TSP2 ^TM with filament and discharge ionization capability

•            Supercritical fluid chromatography (SFC)

Gas Chromatograph

•            High-performance capillary GC with multi-linear programming and split/splitless capillary injector

•            Independently heated, direct coupling capillary interface, operable to 400 °C

•            On-column injector

•            Autosampler

Probes

•            Liquid-cooled solids probe with ion current feedback control

•            Desorption chemical ionization (DCI) probe

•            Fast Atom Bombardment (FAB)

•            BioProbe ^TM (continuous flow FAB)

Data System

•            NIST (NBS) mass spectral library

•            Wiley mass spectral library

•            High-speed/high-output laser printer

•            Additional workstation memory

•            Optical disk drive

•            PC workstation

Installation Requirements

Power

Power: Two 220 V ac -5%+10%, 50/60 Hz at 30 A.

Stable voltage, free of spikes, sags, and surges.

Please refer to the Preinstallation Guide for complete specifications.

Environment

System averages 3500 W (12,000 Btu h ^-1 ). Ambient environment must be 15-26 °C (59-80 °F) with a relative humidity of 20-80% with no condensation.

Dimensions/Weight

Mass spectrometer: 151 cm h x 60 cm w

(allow extra 55 cm [24 in] for card cage removal)

x 118 cm d (60 in x 24 in x 46 in).

Weight: 360 kg (790 Ib).

GC cabinet: 86 cm h x 56 cm w x 59 cm d

(34 in x 22 in x 23 in), provided with GC Option

Data system table: 66 cm h (1340 cm h [53 in] with computer and terminal) x 121 wx 81 cm d. (26 in x 48 in x 32 in).