manufacturer:       B.Braun

model :                   Biostat C-DCU

annotation:           Dokumente engl.

Biostat® C-DCU

In-situ sterilizable lab fermenter

• DCU 3 control system
• Automatic in-situ sterilization
• Interchangeable culture vessels
• Full range of accessories
• “Open frame” design

The Biostat® C-DCU is a compact laboratory scale fermentor with in-situ sterilizable culture vessels up to 30l working volume, the Biostat® C-DCU supports both microbial and cell culture applications.

For cell culture, a full line of accessories like spinfilters, impellers, and gasmix units are available.

This bioprocess system combines the proven process hardware of the Biostat® C with the advanced DCU 3 local control system.

The extensive digital, analog and serial expansion options of the DCU 3 are essential elements for supporting both standard and advanced pro­cess control strategies.

The modular design consists of the culture vessel, the supply unit, a control cabinet and a DCU 3.

The open frame design of the supply unit provides ready access and ease of mainten­ance for all process piping and actuators.

The interchangeable jacketed, stainless steel culture vessels are available with 10 l, 15l, 20l and 30l working volume in a height : diameter ratio of 3:1 or 2:1.

The servomotor of the top-drive agitator is used to maximize performance and to keep removal simple.

• New: “BBI Safety-Port”
• Includes massflow controller
• Multiple cascade controller for pO ₂
• Choice of electrical or steam heating system
• Integrated RS 422 host computer interface

The stainless steel control cabinet includes four, built-in peristaltic pumps and is desi­gned to provide enough space for further installations of additional equipment.

The DCU (Digital Control Unit) is a local control system, specially tailored to biopro­cess (fermentation/cell cul­ture) automation. In its third generation, there are nearly 1500 worldwide.

Standard Biostat® C-DCU automation functionality in­cludes process measure­ments, calibration routines, and a standard set of control loops. An automatic steriliza­tion sequence for the culture vessel, inclusive of the air inlet and exhaust filters, is also standard.

Addional standard software features include: a multiple cascade controller for dissol­ved oxygen, setpoint control profiles, dosing counters for built-in pumps or gasmix val­ves (optional) and the “high foam” emergency shut-down.

Furthermore, standard opti­ons include pressure measu­rement and control, weight measurement and control, and redox and turbidity mea­surement, among others.

Advanced software modules like gravimetric flow control, various gasmixing strategies and nutrient feed strategies may be implemented. Pro­cess specific configurations may also be developed.

The software is developed under a quality control system following the GAMP (Good

Automated       Manufacturing Practice) guidelines.

The DCU 3 is operated using a graphical interface on a flat panel touch-screen. This intui­tive interface eases screen navigation and the changing of parameters, keeping the learning curve to a minimum.

Optionally, for cGMP pro­duction environments, the Biostat® C-DCU offers valida­tion support features. These include a three level password system for user access con­trol, logging of all events and user actions, and compre­hensive software documen­tation. Drawings and data for major components and mate­rials of construction would also be included in this documentation.

The Biostat ® C-DCU is desi­gned to meet your needs.