The ACQUITY UPLC M-Class system enables reliable, high-resolution chromatographic separation processes that are optimized for columns from 75 µm to 1.0 mm inner diameter. The high pressure, direct (unsplit) solvent and sample management system is designed to minimize dispersive and adsorptive losses. The new sample manager and corresponding valve and trap management module ensure maximum sample recovery and superior chromatographic resolution through efficient use of sub-2?m particles for a variety of system and column configurations, providing extensive application flexibility. Waters Acquity M-Class UPLC ?BSM Micro Binary Solvent Manager. Art. No. 186016003. Number of solvents. Up to four, in combination of two: A1 or A2 and B1 or B2. Solvent conditioning. Integrated vacuum degassing, six lines, two of which are for injection needle rinsing/solvent expulsion. Gradient formation. High pressure mixing, binary gradient. Primary check valves. Intelligent intake valves (i 2 valve). Pump composition precision. <0.25 min SD based on six repeated injections. Compressibility compensation. Automatic, no user intervention required. Priming. Automatic, user programmable; Wet priming runs at a flow rate of 4 ml/min. Pump seal flushing. Equipped with an integrated, programmable active flush system to flush the back of the high pressure seals and pistons. Flow ramping. User selectable from the method editor. Primary wet materials. Blend of UHMWPE, MP35N, titanium alloy, gold, sapphire, ruby, cubic zirconia, DLC, fluoropolymer, fluoroelastomer, PEEK, PEEK blend, PPS and fused silica. Mixing options. Optional mixer for microscale (1.0 mm i.d.) Labprocure is responsible for this device.