The Leica RM2255 is a motorized rotary microtome. The instrument features a safety handwheel with a centrally positioned handle and a mechanical locking mechanism. All controls and LEDs are clearly arranged in a separate control panel. The controls are logically grouped into functional groups and are easily identifiable. Sample retraction can be deactivated. In manual mode, the retraction speed can be adjusted. In motorized mode, the retraction speed varies with the selected sectioning depth. An LED indicates when the sample has been retracted. The electric coarse feed operates at two speeds. In sectioning mode, the coarse feed buttons have a STEP function. Three motorized sectioning modes (CONT, SINGLE, and STEP) and a manual sectioning mode, the rocking mode (ROCK), are available. In rocking mode, a brief back-and-forth movement of the handwheel is sufficient to create a section. Section thickness adjustment range: 0.50 to 100 µm. Adjustable values: from 0.50 µm to 5.0 µm in 0.5 µm increments, from 5.0 to 20.0 µm in 1.0 µm increments, from 20.0 to 60.0 µm in 5.0 µm increments, and from 60.0 to 100.0 µm in 10.0 µm increments. Trim thickness adjustment range: 1 to 600 µm. Adjustable settings: 1.0 to 10.0 µm in 1.0 µm increments, 10.0 to 20.0 µm in 2.0 µm increments, 20.0 to 50.0 µm in 5.0 µm increments, 50.0 to 100.0 µm in 10.0 µm increments, and 100.0 to 600.0 µm in 50.0 µm increments. Sample feed: 28 mm ±1 mm, driven by a stepper motor. Vertical stroke: 70 mm. Maximum cross-sectional area without re-alignment: 65 mm². Maximum cross-sectional area with re-alignment: 60 mm². Sample advance in manual cutting mode: 5 to 100 µm in 5 µm increments and can be deactivated. Sample advance in motorized cutting mode: dependent on the cutting speed, also deactivated. Electric coarse feed at 300 µm/s and 900 µm/s. Cutting speed: 0; 0.5 to 420 mm/s ± 10%. Return speed: approx. 120 to 420 mm/s ± 10%. Shift of the cutter head base plate: north-south ± 24 mm, east-west ± 23 mm. Maximum sample size (W x H x D): 50 x 60 x 40 mm. Sample orientation: horizontal 8°, vertical 8°. Working height (knife blade): 100 mm (measured from the base plate). Working height (knife blade): 168 mm (measured from the table). Dimensions (W x D x H): 413 x 618 x 305 mm. Weight: 37 kg. Control panel dimensions (W x D x H): 121 x 166 x 50 mm. Weight: 660 g