The Agilent 8800 ICP-QQQ is the world's first triple quadrupole ICP-MS - a truly groundbreaking instrument that is changing the ICP-MS landscape. The 8800 ICP-QQQ combines the proven matrix tolerance and dynamic range capabilities of the 7700 Series ICP-MS with the unbeatable interference rejection performance of MS/MS. The result is a unique analytical tool that can easily handle even the most difficult samples and applications. Technical and performance highlights of the 8800 ICP-QQQ include: • Unique tandem mass spectrometer configuration. • Innovative MS/MS mode for unprecedented interference rejection in the collision/reaction cell. • Optimized vacuum system delivers a higher signal-to-noise ratio than conventional quadrupole ICP-MS. • The highest full sensitivity ever seen in ICP-MS (theoretically <10-14). • Many critical hardware components and the ICP-MS MassHunter software platform are shared with the proven 7700 Series ICP-MS. Overview of the Agilent 8800 ICP-QQQ. ICP-QQQ: Redefining ICP-MS performance. The revolutionary Agilent 8800 Triple Quadrupole ICP-MS (ICP-QQQ) combines the proven capabilities of the 7700 Series Quadrupole ICP-MS (ICP-QMS) with the unique performance of MS/MS that is only possible with a true tandem MS instrument. The term "triple quadrupole" is used in organic mass spectrometry to describe instruments that have two separate quadrupole mass filters in series, separated by a chamber (or cell) in which collision and reaction processes take place. The collision/reaction cell can contain one of several different types of ion guides (quadrupole, hexapole, or octapole), but by convention, instruments containing any of these ion guides are generally referred to as "triple quadrupole" mass spectrometers. The key aspect of the triple quadrupole configuration is that all of these instruments have two separate mass filters, one before and one after the collision/reaction cell. In ICP-MS, this configuration is unique to the 8800 ICP-QQQ. The triple quad configuration of the Agilent 8800 ICP-QQQ provides fundamentally improved performance in interference rejection in the collision/reaction cell, particularly in reaction mode. Collision mode in ICP-QMS (with He cell gas) is effective in removing polyatomic interference in high matrix samples. However, He mode cannot ensure complete removal of intense interference on some important analytes such as P, S and Se, or enable ppt-level analysis in high purity materials. For analysis of high purity materials using ICP-QMS, reaction mode (with reactive cell gas) may be more effective than He mode for certain analytes. But reaction mode on ICP-QMS often leads to unpredictable results due to the inability to reject non-target ions upstream of the cell. This leads to the formation of unpredictable, sample-dependent product ions from the variable reaction processes in the cell, especially when the matrices are complex or variable. The Agilent 8800 ICP-QQQ solves these problems and enables full use of reaction mode